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Sexually Transmitted Diseases/ Infections (STDs/STIs) are a major public health problem and a leading cause of morbidity among women in developing countries like Bangladesh. According to WHO, 2006, STDs/STIs ranks second as a cause of healthy life loss among women in the reproductive age group. This research has been conducted on examining knowledge awareness and prevention of STDs among women. It was conducted in two selected slums (Kathalbagan’s Lakkhi slum and Moghbazar slum) of Dhaka city in Bangladesh. This study was conducted through quantitative research and convenience sampling techniques. A structured questionnaire was developed to collect data on knowledge awareness and prevention of STDs/STIs. The study shows that 68.3% of respondents have knowledge about STDs, in this research majority of respondents are not aware of risk factors associated with STDs. This study examines that, for building awareness, majority of respondents preferred “Radio and Television” as the most important media that can build awareness for STDs among slum women. Special counseling is mandatory for the victims, along with sex education. Awareness about healthy sexual behaviors, a hygienic lifestyle, and instruction about the correct use of male condoms should be promoted to reduce the risk of health complications and greatly reduce the spread of STDs not in Bangladesh but also in developing countries.