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This study examines the effect of some economic and non-economic factors on corruption.  It tests a number of hypotheses formulated around the impact of specific dimensions on increasing or reducing corruption in the Middle East and North Africa Region over a time series from 2008 to 2018. The objective of this study is to illuminate the impact of several independent factors (average income, economic freedom, education, income distribution and globalization) on corruption increase or decrease in the MENA region taking a few countries as a sample case. To reach this end, secondary data is employed and retrieved from secondary sources using published reports and indexes and official websites and databases maintained by various research institutions. The results are tested using panel data regression analysis as a statistical tool for data analysis and hypotheses testing. Findings indicate a significant effect of the presented economic and non-economic determinants on corruption in these sample countries except income distribution which shows an insignificance effect.