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This article investigates the impact of Supply Chain Relationship Management (SCRM) on operational efficiency, with a specific focus on the mediating role of information sharing. SCRM has been widely recognized for promoting collaboration and improving operational outcomes in supply chains. However, the effectiveness of SCRM practices is significantly enhanced when accompanied by robust information-sharing mechanisms. The study utilizes Structural Equation Modeling (SEM) to analyze data collected from 108 supply chain professionals in the Sunyani Municipality, Ghana. The results show that information sharing plays a critical role in mediating the relationship between SCRM and operational efficiency, highlighting its importance as a mechanism for facilitating better coordination, reducing operational costs, and improving lead times. These findings offer valuable insights into how inter-organizational collaboration and effective information exchange contribute to operational improvements in supply chains, particularly within the pharmaceutical sector in developing economies. The study contributes both theoretical and practical perspectives on supply chain management.