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Over the years, governments in Ghana have provided various stimulus packages for local entrepreneurs to rejuvenate and expand their businesses while setting up new companies. The question is, how talented are the youth in entrepreneurship? This paper sought to review the extant literature on the impact of skill acquisition on entrepreneurship development and progress in Ghana. The Systematic Literature Review (SLR) approach was used to search for relevant journal articles from Scopus, Emerald Insight, and Google Scholar search engines. The search criteria were limited to journal articles with the keywords “skill acquisition”, “entrepreneurship,” and entrepreneurship development” from 1970 to 2020. Using the SLR technique, a total of 45 articles were identified, and 21 were relevant to the research focus. The review identified that skill acquisition significantly influences entrepreneurship development. It is recommended that entrepreneurship skill acquisition should be integrated in the Ghanaian education system right from the elementary level. Again, tertiary institutions in Ghana should have entrepreneurial centers for practical sessions.