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Healthcare delivery relies on human resource management to ensure quality. However, employee performance dropped from 2019 to 2022, highlighting the need to address job fatigue, which lowers performance. This study examines how mindfulness and emotional intelligence mediate the effects of occupational fatigue on medical and paramedic performance. This integrated study intends to understand healthcare job performance and improve medical professionals' competency and well-being in Indonesia. A 5% margin of error was used to choose 213 medical staff and paramedics from the Mojokerto City Government Health Agency in Indonesia using the Slovin algorithm. The Sobel Test and SEM with AMOS were used to analyse data. Mindfulness and emotional intelligence decreased considerably with job burnout, affecting job performance. Mindfulness and emotional intelligence also improved job performance. The results also showed that emotional intelligence and mindfulness moderate the job burnout-performance link. These findings show that emotional and psychological aspects are crucial to understanding how job fatigue affects employee performance.