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This research examines digital transformation and corporate entrepreneurship as strategies to face disruption in the global era. The study is motivated by technological advances such as AI, Big Data, and IoT that drive a shift in business paradigms. The research objectives include analyzing corporate entrepreneurship strategies to spur innovation, conducting case studies of companies successfully implementing corporate entrepreneurship, identifying barriers and challenges, and evaluating implications for companies in the digital era. The research employs a qualitative approach using case studies and literature analysis to integrate primary and secondary data through triangulation and thematic analysis. Findings indicate that the application of innovative strategies through corporate entrepreneurship enhances competitive advantage, accelerates digital adaptation, and optimizes both internal and external collaboration. Key barriers—such as conservative organizational culture and limited resources—can be overcome through structural changes and investments in technology and human resources. The conclusions emphasize the importance of synergy between digital innovation and corporate entrepreneurship in creating sustainable company growth. This study contributes strategically to the development of adaptive business models amid digital disruption. The findings are expected to serve as a reference for practitioners and academics in designing innovative strategies that respond effectively to global market dynamics, thereby enhancing operational efficiency and achieving a sustainable competitive edge.