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This study examines how practical theology and social work may collaborate to eradicate gender-based violence and femicides in South Africa. Faith communities can reinterpret religious teachings, criticise patriarchal behaviours, and help survivors spiritually and psychosocially. Social workers contribute to the problem through advocacy, trauma-informed treatment, therapy, psychoeducation, and community mobilisation. The study recommends church-based efforts, social work techniques, and a theological framework to combat GBV, help victims, and promote social change and inclusivity. The study supports advocacy, transformation, social justice, and reconciliation through social work and faith-based solutions. Practical theology can integrate spiritual care, advocacy, community-based rehabilitation, and psychosocial assistance with social work. This study uses a literature review to discuss femicide and gender-based violence (GBV) in South Africa through an interdisciplinary debate between Practical Theology and Social Work.