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Cancer remains a significant public health concern worldwide, necessitating ongoing efforts to understand its epidemiology and im- prove patient care. This cross-sectional epidemiological study, based on third-party statistics collected over a period of one and a half years (from October 2021 to March 2023), aimed to examine the sociodemographic characteristics and clinical profiles of cancer patients in the Littoral Region of Cameroon. Data were gathered through structured questionnaires, with strict adherence to ethical considerations. The study included 307 cancer patients.Key findings indicate a predominance of breast cancer, a significant proportion of patients aged 41-50 years, and a majority diagnosed at stage 4 of the disease. These results highlight the urgent need for early detection and targeted interventions in cancer care. Furthermore, the research explores factors contributing to the high rate of late-stage cancer diagnoses, such as lack of awareness, insufficient diagnostic facilities, and economic barriers that prevent many patients from seeking timely medical help. Based on these findings, the study recommends the development of comprehensive cancer management strategies, including enhancing public health education, improving diagnostic and treatment capacities, and implementing policy reforms aimed at making healthcare more accessible and affordable. Such measures are essential for reducing the burden of cancer in Cameroon and improving the overall health outcomes for its population.