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The resumption of indirect US-Iran negotiations in 2026, mediated by Qatar, Pakistan, and Oman, represents a critical test case for contemporary conflict resolution in the Arabian Gulf. While existing studies have extensively examined US-Iran hostility through the lenses of nuclear proliferation, sanctions regimes, and military deterrence, the mediating role of small-state actors, particularly Qatar, remains theoretically underdeveloped. This paper addresses this gap by constructing an analytical framework for understanding Qatar’s mediation strategy in the 2026 shuttle diplomacy efforts, with a specific focus on the reopening of the Strait of Hormuz and broader de-escalation. Drawing upon mediation theory, neoclassical realism, and hedging literature, the proposed framework conceptualizes Qatari mediation along three analytical dimensions: (1) structural enablers: Qatar’s strategic geography, financial resources, and institutionalized relationships with both Washington and Tehran; (2) strategic motivations: Doha’s pursuit of regional stability, protection of its maritime economic interests, and preservation of its security guarantee from the US while maintaining ties with Iran; and (3) tactical modalities: the indirect, rotating mediation structure involving multiple state intermediaries, draft proposal exchanges, and confidence-building measures. Applying this framework to the 2026 negotiation process reveals two primary findings. First, Qatar’s effectiveness as a mediator hinges on its perceived neutrality and its unique access to both parties’ red lines: the US demand for comprehensive nuclear constraints and Iran’s insistence on sanctions relief and security recognition. Second, the indirect shuttle format, while slower than direct talks, enables both sides to explore compromise without domestic political backlash, transforming the Strait of Hormuz from a flashpoint into a bargaining chip. The paper concludes that Qatar’s mediation, while promising, faces structural limitations inherent to asymmetrical power relations. Ultimately, this framework offers scholars a replicable model for analyzing small-state mediation in great-power conflicts and provides policymakers with insights into the conditions that facilitate or obstruct Gulf diplomacy