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In Southern Africa, the human immunodeficiency virus constitutes a significant public health challenge, characterised by elevated rates of new infections in rural populations. Conversely, biomedical interventions have facilitated advancement. The incorporation of Indigenous Knowledge Systems into Human Immunodeficiency Virus preventive techniques is still little investigated. This systematic analysis assesses the incorporation of Indigenous Knowledge Systems into community-based HIV prevention strategies in Southern Africa. This systematic review complied with the PRISMA principles. A search was performed across various electronic databases, including PubMed, Google Scholar, and CINAHL, for papers published from 01 January 2015 to 31 June 2025. A total of 51,972 studies were discovered, of which 14 matched the inclusion criteria and were evaluated. The analysis revealed that incorporating Indigenous Knowledge Systems into community-based HIV prevention programs in Southern Africa improved cultural relevance, community involvement, and trust in health initiatives. Traditional healers significantly contributed to counselling, education, and the increase of HIV testing in rural regions, leading to enhanced service accessibility and diminished stigma. Notwithstanding these advantages, several projects nevertheless lacked official policy support and organised collaborations between conventional and biological health sectors.

The Universal Testing and Treatment (UTT) program aimed to improve human immunodeficiency virus (HIV) outcomes by initiating immediate antiretroviral therapy (ART). However, UTT faced challenges, including high attrition rates and loss to follow-up (LTFU), particularly in South Africa, where implementation has sometimes led to increased treatment discontinuation. This study investigated HIV UTT program uptake and LTFU rates among people living with HIV (PLWHIV) in Moretele Sub-district, South Africa. A quantitative, observational retrospective design evaluated UTT effectiveness in rural HIV care. Adult clients initiating ART between January 2020 and January 2022 across nine clinics in Moretele Sub-district were included. A random sample of 500 medical records was analyzed using Tier.net and DHIS software for record identification. Data analysis using STATA 18.0 included descriptive statistics, bivariate analysis, and logistic regression to identify factors influencing retention. Of 203 records analyzed, (30.8%) were aged 30–39, and 52.8% were female. Most clients were single (61.8%) and employed (51.6%). Same-day ART initiation was high (83.8%), yet 70% were LTFU, 25% transferred, 4.4% stopped treatment, and 0.6% died. Clients aged 30–39 had higher odds of LTFU (adjusted OR = 1.77; p=0.007). Gender, marital, and income status showed no significant association. While UTT enables rapid ART initiation, high LTFU rates, especially among younger, male, and employed individuals, hinder success. Strategies to improve retention should focus on same-day initiators and community engagement. This study highlights critical challenges in UTT implementation, emphasizing the need for targeted interventions to address LTFU and enhance retention in HIV care programs.

The human immunodeficiency virus (HIV) testing services (HTS) are as important as any other healthcare service; hence clients should be encouraged to use them. The Universal Testing and Treatment (UTT) initiative is one of the ways for improving HIV outcomes by commencing rapid antiretroviral medication (ART). An explorative-descriptive qualitative study was followed to understand the motivation for accepting and utilization of HTS through the UTT strategy. The study was conducted in three selected PHC facilities around North-West province, Bojanala district, Kgetleng sub-district. Data was analysed using thematic content with the support of NVivo 12 software. Four main themes with supporting sub-themes emerged. The study findings showed that the majority of participants were not knowledgeable about or aware of the strategy until they tested positive in their clinics. HTS are still underused as participants presented to the facilities only when seriously ill, had symptoms or were pregnant. Some participants accepted their status and treatment because they were already sick and had no choice but to take treatment. Despite the different emotions, others were able to accept their treatment and status. Some disclosed and received support from family, partners and friends, while others had not. Fear of stigmatisation when seen frequently at the clinic was also noted. This article's findings can influence policymakers involved in HIV testing and UTT methods.

The number of new HIV cases worldwide has gradually declined; however, South African adolescent females and young women continue to account for the most infections. Although the availability and accessibility of antiretroviral drugs have improved the survival rates of women, some still transmit HIV to their children despite the availability of HIV prevention interventions, resulting in a dual responsibility for the care of themselves and their infected children. This study aims to explore the challenges experienced by caregivers of HIV-infected children in Limpopo Province. The study employed qualitative, exploratory, and descriptive designs, and data was collected from 12 caregivers through semi-structured interviews. Data were analysed using Tesch’s eight steps of analysis. The study identified three challenges facing caregivers of HIV-positive children. Caregivers struggled with disclosure and stigma, finding it difficult to reveal the child's HIV status. The burden of care was significant, including the management of the child's unstable health, ensuring compliance with treatment, and attending frequent hospital visits. The unemployment rate posed a financial burden, particularly in arranging hospital travel costs and providing adequate nutrition to HIV-infected children. These challenges highlight the need for increased support for caregivers of HIV-infected children, including education and awareness campaigns to reduce stigma. Policymakers should consider providing financial support to caregivers. A holistic, multisectoral approach involving healthcare, education, social services, and policymakers is essential.

The purpose of the study was to explore the perceptions of church members regarding congregants who are on antiretroviral therapy in Limpopo Province, South Africa. The study was conducted in churches of Vhembe District, Limpopo Province, South Africa. The study utilised an exploratory, descriptive, qualitative research design. The study focused on church members in Vhembe District of Limpopo Province. A non-probability purposive sampling method was used to select church members for participation. The sample size was 30 church members, determined by saturation of data. Semi-structured interviews were utilised to collect data, and data was analysed using Tech's eight steps of the coding process, through the content analysis method. The study yielded four themes, namely, church members’ understanding of antiretroviral therapy, attitudes of church leaders towards congregants on antiretroviral therapy, the roles, and responsibilities of church leaders towards congregants on antiretroviral therapy and, psychosocial challenges faced by congregants on antiretroviral therapy. Church members understood what antiretroviral therapy is used for, and some were specific about its impact in suppressing the viral load and improving the CD4 count. However, some church leaders were reported to be negative towards congregants on ART. As much as church members knew about ART and its use, people living with HIV/AIDS were subjected to rejection, discrimination, and stigmatization and lacked general support in churches. HIV/AIDS awareness campaigns are necessary to impart to church members information that is readily available, appropriate, and effective. These campaigns could be delivered through workshops targeting church members, including both church leaders and congregants.  

The study aimed to explore and describe the experiences of inmates living with HIV/AIDS regarding ARV adherence in correctional services in Limpopo Province. A qualitative, exploratory, descriptive and contextual approach with a constructive paradigm was employed to gain insight into the experiences of inmates living with HIV and AIDS. Non-contact telephone interviews through transparent windows were conducted with the inmates living with HIV/AIDS (n=20) from May 2021 until September 2021 in the correctional service facilities in Limpopo Province. Telephone interviews were audio-recorded and transcribed verbatim from Tshivenda, Sotho, and Tsonga into English. Data were analyzed using eight steps according to Tech’s method of qualitative analysis to determine themes and subthemes. The results indicate the burden of taking multiple medication regimens, fear of stigma and break of confidentiality, shortage of nursing staff and high workload, professional nurses ‘insufficient’ adherence counseling and health-related information and education, inmates transitioning between correctional and police station facilities, insufficient provision of meals and meals unrelated to treatment times, and inconsistent criteria for provision of a special diet as factors contributing to medication adherence for detained inmates living with HIV/AIDS in the correctional service environment. The study concluded that optimal adherence to ARV treatment for inmates living with HIV/AIDS during incarceration is crucial to achieving viral suppression and improving medication outcomes for inmates in correctional service facilities.