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The study aimed to investigate factors influencing the intention to adopt e-health tools for accessing digital mental health services among university staff at a selected South African higher education institution. A quantitative case study was conducted at a single university in Cape Town, South Africa. Data was collected from 348 respondents using online questionnaires and analysed using descriptive statistics and multiple regression. The results revealed that stable internet access at home did not significantly influence the intention to adopt e-health tools (p =0.698, ? = -0.020), but concerns about internet costs were a barrier (p = 0.011, ? = 0.131). University staff who used multiple devices (p = 0.014, ? = 0.136) and preferred e-health tools over traditional face-to-face services were more likely to adopt them (p < 0.001, ? = 0.319). Moreover, social media usage (p < 0.766, ? = 0.016), searching for digital mental health services (p <0.107, ? = 0.085), and awareness of free university services (p < 0.307, ? = -0.058), DMHS providers (p < 0.529, ? = 0.038), and fourth industrial revolution technologies (p < 0.106, ? = -0.091) did not significantly influence adoption intentions. The study contributes to sustainable digital mental health support for university staff in South Africa. The results could potentially be applicable to similar contexts globally. Thus, helping to achieve the Sustainable Development Goal 3 of the United Nations of ensuring good health and wellbeing.