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Writing and publishing scientific and rigorous work needs a high level of integrity and adherence to ethical guidelines. Several publications have been rejected by authentic journals as a result of not adhering to a deontological standpoint. This laxity has posed deadly repercussions to the beholder including ruining its institutional image in academic scholarship. Notwithstanding, numerous writers are acquainted with the consequences of not observing ethical standards in research and publication, yet in trying to put up their pieces of work get caught in the same quandary. Anchored on a thematically oriented review of literature, it was imperative to try to explain the key ethical misconduct bases in research and publication. To fulfil this quest many journal articles were analysed. It was found that numerous aspects form the basis for misconduct in research and publication including; the pressure to ‘publish or perish’, the limitation of mentorship and guidance programs, knowledge on research and publication, promotion and academic advancement, competition among colleagues, workload pressure, financial motives, pressure from individual morality, and the challenge of research culture. Consequently, it is imperative to note that to publish a scholarly piece of work, adhering to ethical standards is non-negotiable.