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Malang City Hospital is one of the hospitals appointed by the Malang City government in handling Covid-19 patients. This study aims to analyze the effect of nurse engagement and affective commitment on nurse performance in the health sector through self-efficacy as a mediating variable. Data were taken from 102 nurses at the Malang City Hospital using the Structurals Equation Model analysis method using the Variances Based SEM approach or better known as Partial Least Square (PLS). The results of this study indicate that nurse engagement and affective commitment have no effect on nurse performance. Self-efficacy is able to mediate the effect of nurse engagement and affective commitment on nurse performance.