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The purpose of this paper is to present a science-based narrative of the impact of the Ebola Virus Disease (EVD) on the supply chains of the major commodities of Liberia. Scientific literatures from appropriate journals, newspapers, trade data of applicable ministries and governmental agencies, data on Ebola from websites of World Health Organization (WHO), Food and Agricultural Organization (FAO), Center for Disease and Control and Prevention (CDC), World Bank, the International Monetary Funds (IMF) and other relevant institutions are used extensively while also employing a market chain approach to represent the overall supply chains of these products. The review reveals, among others, the significant disruption to the flow of goods and the decrease in output of the main export commodities of Liberia. It also shows a fall in the real GDP growth rate of the Mano River Basin (MRB) countries during the Ebola years. The paper identifies that the specific mechanisms through which the supply chains were disrupted were as a result of fear and government’s regulation. Additionally, it provides a practical conduit for the diversification of the rubber industry. Given the complex web of supply chains of just a single product, this effort is in no way an exhaustive review on the impact of the EVD on supply chains of commodities dealt with herein, let alone the overall impact of EVD on the country as a whole. Obviously, this review is also limited in terms of scope and extent. This review is a useful introduction to investigators who might want to commit to research in this particular aspect of the impact of the EVD vis-a-vis its impact on supply chains in Liberia or on a broader level, the MRB Countries.